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MI-136 inhibits DHT-induced expression of androgen receptor (AR) target genes. MI-136 treatment inhibits the expression of genes that were bound to ASH2L after AR stimulation.
In vivo, treatment of VCaP tumor-bearing mice with MI-136 (40 mg/kg) led to a modest but significant reduction in tumor volume with no effect on mouse body weight.
| Molecular Weight | 470.51 |
| Formula | C23H21F3N6S |
| CAS Number | 1628316-74-4 |
| Solubility (25°C) | DMSO: ≥ 30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Androgen Receptor Products |
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