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MI-136

Cat. No. M9149
MI-136 Structure
Size Price Availability Quantity
10mg USD 180  USD180 In stock
50mg USD 650  USD650 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

MI-136 inhibits DHT-induced expression of androgen receptor (AR) target genes. MI-136 treatment inhibits the expression of genes that were bound to ASH2L after AR stimulation.

In vivo, treatment of VCaP tumor-bearing mice with MI-136 (40 mg/kg) led to a modest but significant reduction in tumor volume with no effect on mouse body weight.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 470.51
Formula C23H21F3N6S
CAS Number 1628316-74-4
Purity >98%
Solubility DMSO: ≥ 30 mg/mL
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: MI-136 supplier, Androgen Receptor, inhibitors

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