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Metronidazole

Cat. No. M3311
Metronidazole Structure
Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
1g USD 40  USD40 In stock
5g USD 55  USD55 In stock
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Quality Control & Documentation
Biological Activity

Metronidazole is a nitroimidazole antibiotic that is used specifically for anaerobic bacteria and protozoa.

Product Citations
Chemical Information
Molecular Weight 171.15
Formula C6H9N3O3
CAS Number 443-48-1
Solubility (25°C) DMSO 27 mg/mL
Storage 2-8°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Risheng Zhao, et al. Gastroenterology. Aspirin Reduces Colorectal Tumor Development in Mice and Gut Microbes Reduce its Bioavailability and Chemopreventive Effects

[2] Simon A Dingsdag, et al. Metronidazole: an update on metabolism, structure-cytotoxicity and resistance mechanisms

[3] Hilde Fjeld, et al. Is combining metronidazole and alcohol really hazardous?

[4] V Martinez, et al. Metronidazole

[5] C D Freeman, et al. Metronidazole. A therapeutic review and update

[6] B E Scully. Metronidazole

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