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Metronidazole Benzoate

Cat. No. M20944
Metronidazole Benzoate Structure

Benzoyl metronidazole

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Biological Activity

Metronidazole Benzoate is the benzoate ester of metronidazole, a synthetic nitroimidazole derivative with antiprotozoal and antibacterial activities.

Chemical Information
Molecular Weight 275.26
Formula C13H13N3O4
CAS Number 13182-89-3
Solubility (25°C) DMSO 55 mg/mL
Water 1 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Yonas Brhane. PLoS One. Retraction: Evaluation of carboxymethylated plectranthus edulis starch as a suspending agent in metronidazole benzoate suspension formulations

[2] Bushra Rafique, et al. J Biomol Struct Dyn. Novel copper complexes of metronidazole and metronidazole benzoate: synthesis, characterization, biological and computational studies

[3] C Mans, et al. J Small Anim Pract. Effects of commercial metronidazole and metronidazole benzoate suspensions on food intake in chinchillas

[4] Bernardo Guevara, et al. Dig Dis Sci. Helicobacter pylori: A Review of Current Diagnostic and Management Strategies

[5] Sherin Jacob, et al. Dermatol Ther. Treatment of Demodex-associated inflammatory skin conditions: A systematic review

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Keywords: Metronidazole Benzoate, Benzoyl metronidazole supplier, Anti-infection, inhibitors, activators

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