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Metoprolol Succinate

Cat. No. M5784
Metoprolol Succinate Structure
Size Price Availability Quantity
50mg USD 70  USD70 In stock
100mg USD 135  USD135 In stock
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Quality Control & Documentation
Biological Activity

Metoprolol Succinate (Toprol XL) is a selective β1 receptor blocker used in treatment of several diseases of the cardiovascular system, especially hypertension.

Chemical Information
Molecular Weight 652.82
Formula C34H56N2O10
CAS Number 98418-47-4
Solubility (25°C) 10 mM in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Pasternak B, et al. JAMA Intern Med. Association of treatment with carvedilol vs metoprolol succinate and mortality in patients with heart failure.

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