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Methylisoindigotin

Cat. No. M2599

All AbMole products are for research use only, cannot be used for human consumption.

Methylisoindigotin Structure
Synonym:

Natura-α, N-Methylisoindigotin, Dian III

Size Price Availability Quantity
10mM*1mL in DMSO USD 85  USD85 In stock
5mg USD 78  USD78 In stock
10mg USD 108  USD108 In stock
25mg USD 220  USD220 In stock
50mg USD 330  USD330 In stock
100mg USD 510  USD510 In stock
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Quality Control & Documentation
Biological Activity

Meisoindigo inhibites the growth of leukemic cells by inducing marked apoptosis and moderate cell-cycle arrest at the G(0)/G(1) phase. Meisoindigo induces myeloid differentiation, as demonstrated by morphologic changes, up-regulation of CD11b, and increases nitroblue tetrazolium reduction activity in all cell lines tested. Meisoindigo induces apoptosis, up-regulated p21 and p27, and down-regulated Bcl-2 in primary AML cells. Meisoindigo inhibits HT-29 cell proliferation (IC(50) 4.3 mmol/L), arrests HT-29 cells in G2/ M phase and induces HT-29 cell apoptosis effectively.

Chemical Information
Molecular Weight 276.29
Formula C17H12N2O2
CAS Number 97207-47-1
Solubility (25°C) DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Lee CC, et al. Leuk Lymphoma. Meisoindigo is a promising agent with in vitro and in vivo activity against human acute myeloid leukemia.

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Keywords: Methylisoindigotin, Natura-α, N-Methylisoindigotin, Dian III supplier, inhibitors, activators

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