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Cat. No. M2599
Methylisoindigotin Structure

Natura-α, N-Methylisoindigotin, Dian III

Size Price Availability Quantity
10mM*1mL in DMSO USD 85  USD85 In stock
5mg USD 78  USD78 In stock
10mg USD 108  USD108 In stock
25mg USD 220  USD220 In stock
50mg USD 330  USD330 In stock
100mg USD 510  USD510 In stock
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Quality Control & Documentation
Biological Activity

Meisoindigo inhibites the growth of leukemic cells by inducing marked apoptosis and moderate cell-cycle arrest at the G(0)/G(1) phase. Meisoindigo induces myeloid differentiation, as demonstrated by morphologic changes, up-regulation of CD11b, and increases nitroblue tetrazolium reduction activity in all cell lines tested. Meisoindigo induces apoptosis, up-regulated p21 and p27, and down-regulated Bcl-2 in primary AML cells. Meisoindigo inhibits HT-29 cell proliferation (IC(50) 4.3 mmol/L), arrests HT-29 cells in G2/ M phase and induces HT-29 cell apoptosis effectively.

Chemical Information
Molecular Weight 276.29
Formula C17H12N2O2
CAS Number 97207-47-1
Solubility (25°C) DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Lee CC, et al. Leuk Lymphoma. Meisoindigo is a promising agent with in vitro and in vivo activity against human acute myeloid leukemia.

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Keywords: Methylisoindigotin, Natura-α, N-Methylisoindigotin, Dian III supplier, inhibitors, activators

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