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Methuosis inducer 1 

Cat. No. M25546
Methuosis inducer 1  Structure
Size Price Availability Quantity
5mg USD 285  USD285 In stock
10mg USD 440  USD440 In stock
25mg USD 820  USD820 In stock
50mg USD 1280  USD1280 In stock
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Biological Activity

Methuosis inducer 1 is a potent methuosis inducer. Methuosis inducer 1 has anticancer activity.

Chemical Information
Molecular Weight 487.48
Formula C27H20F3N5O
CAS Number 2240205-30-3
Form Solid
Solubility (25°C) DMSO 15 mg/mL (ultrasonic and warming and adjust pH to 3 with HCl)
Storage Powder -20°C
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Barbara Del Bello, et al. Cancer Cell Int. The autophagy inducer trehalose stimulates macropinocytosis in NF1-deficient glioblastoma cells

[2] Núria Bielsa, et al. Int J Mol Sci. Methuosis Contributes to Jaspine-B-Induced Cell Death

[3] Jun Wu, et al. J Enzyme Inhib Med Chem. Design, synthesis, and biological evaluation of 5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)-1 H-Indole-2-Carbohydrazide derivatives: the methuosis inducer 12A as a Novel and selective anticancer agent

[4] Claudio D'Amore, et al. Biochim Biophys Acta Mol Cell Res. "Janus" efficacy of CX-5011: CK2 inhibition and methuosis induction by independent mechanisms

[5] Hyelim Cho, et al. ACS Omega. Indolyl-Pyridinyl-Propenone-Induced Methuosis through the Inhibition of PIKFYVE

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Keywords: Methuosis inducer 1  supplier, inhibitors, activators


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