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Mepazine is a potent and selective inhibitor of MALT1 protease, with IC50s of 0.83 and 0.42 μM for inhibition of full-length GSTMALT1 and GSTMALT1 325-760 segments, respectively, and also affects the viability of ABC-DLBCL cells by enhancing apoptosis. Mepazine also affects the viability of ABC-DLBCL cells by enhancing apoptosis.
| Molecular Weight | 310.46 |
| Formula | C19H22N2S |
| CAS Number | 60-89-9 |
| Form | Solid |
| Solubility (25°C) | DMSO 100 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[4] H C DENBER. Am J Psychiatry. Ineffectiveness of mepazine (pacatal)
[5] N BRUCKMAN, et al. Am J Psychiatry. Mepazine (pacatal); further report
| Related MALT1 Products |
|---|
| Mepazine hydrochloride
Mepazine hydrochloride (Pecazine hydrochloride) is a potent and selective MALT1 protease inhibitor with IC50s of 0.83 and 0.42 μM for GSTMALT1 full length and GSTMALT1 325-760, respectively. |
| Val-Arg-Pro-DL-Arg-Fluoromethylketone
Val-Arg-Pro-DL-Arg-Fluoromethylketone is a potent MALT1 inhibitor. |
| MPT-0118
MPT-0118 is an S-enantiomer of methylpiperazine and a MALT1 inhibitor that can be used in studies related to B-cell tumors. |
| SGR-1505
SGR-1505 is an oral potent small molecule allosteric inhibitor of MALT1 that inhibits MALT1 enzymatic activity and demonstrates anti-proliferative activity in ABC-DLBCL cell lines, both BTKi-sensitive (OCI-LY10) and BTKi-resistant (OCI-LY3). SGR-1505 can be used in studies related to B-cell tumors. |
| ABBV-525
ABBV-525 is a MALT1 inhibitor for studies related to B-cell chronic lymphocytic leukemia, diffuse large B-cell lymphoma. |
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