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MD13 

Cat. No. M29808
MD13  Structure
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Biological Activity

MD13 is a macrophage migration inhibitory factor (MIF)-directed PROTAC with a Ki of 71 nM. MD13 can be used for cancer research.

Chemical Information
Molecular Weight 653.68
Formula C35H35N5O8
CAS Number 2758431-97-7
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Tomohiro Shoji, et al. Medicina (Kaunas). Sevoflurane Does Not Promote the Colony-Forming Ability of Human Mesenchymal Glioblastoma Stem Cells In Vitro

[2] Zhangping Xiao, et al. Angew Chem Int Ed Engl. Proteolysis Targeting Chimera (PROTAC) for Macrophage Migration Inhibitory Factor (MIF) Has Anti-Proliferative Activity in Lung Cancer Cells

[3] Parul Ichhpujani, et al. Ther Adv Ophthalmol. Assessing glaucoma deterioration using Spaeth/Richman contrast sensitivity test

[4] C Strewe, et al. Brain Behav Immun. Hyperbaric hyperoxia alters innate immune functional properties during NASA Extreme Environment Mission Operation (NEEMO)

[5] N A Johnson, et al. J Immunol. T cell receptor gene segment usage in a panel of hen-egg white lysozyme specific, I-Ak-restricted T helper hybridomas

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Keywords: MD13  supplier, PROTAC, inhibitors, activators

 
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