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MBX-4132 is a member of a chemical class called oxadiazoles that inhibit trans translation by binding to the bacterial ribosome. MBX-4132, which interferes with protein synthesis by blocking trans translation, has several characteristics that could make it a match for N. gonorrhoeae.
In vivo, a single oral dose of MBX-4132 cured 70 percent of mice who had multidrug-resistant gonorrhea in one animal study.
| Molecular Weight | 338.34 |
| Formula | C18H15FN4O2 |
| Solubility (25°C) | DMSO ≥ 20 mg/mL (Need ultrasonic and warming) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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