Malacidin A is a calcium-dependent antibiotic that is highly active against many drug-resistant pathogens, especially Gram-positive bacteria.
| Molecular Weight | 1249.37 |
| Formula | C56H88N12O20 |
| CAS Number | 2254483-95-7 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related Antibiotic Products |
|---|
| Arylomycin A2
Arylomycin A2 is an antibiotic and lipopeptide type I signal peptidase (SPase I) inhibitor with antibacterial activity. |
| Bleomycin A2 sulfate
Bleomycin A2 sulfate is an antitumor antibiotic that promotes DNA degradation and is also an aspartate/asparagine-β-hydroxylase (AspH) inhibitor with an IC50 of 1.47 μM. |
| G0775
G0775 is a novel antibiotic that penetrates the outer membrane through a porin-independent mechanism and exhibits potent, broad-spectrum antibacterial activity against Gram-negative bacteria. |
| Malacidin B
Malacidin B is a macrocyclic lipopeptide antibiotic that exerts antimicrobial activity in a calcium-dependent manner. |
| Clovibactin
Clovibactin, a novel antibiotic isolated from a soil bacterium and also a phenolphthalein condensate, is inhibitory to a wide range of drug-resistant Gram-positive bacteria, specifically inhibiting the membrane-associated steps of N-acetylglucosaminoglycans (GlcNAc) adherence to the cell wall, as well as the synthesis of peptidoglycan (PGN) and wall phosphatidylsulfonic acid (WTA), interfering with the synthesis of the cell wall and leading to cellular lysis. |
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