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Malabaricone C is an orally active and noncompetitive sphingomyelin synthase (SMS) inhibitor with IC50 values of 3 μM and 1.5 μM for SMS 1 and SMS 2, respectively. Malabaricone C has anti-inflammatory effects, which is found in the fruits of Myristica cinnamomea King. Malabaricone C reduces body weight gain, improves glucose tolerance, and decreases lipid accumulation in the liver, showing significant prevention of high fat diet-induced fatty liver in mice.
| Molecular Weight | 358.43 |
| Formula | C21H26O5 |
| CAS Number | 63335-25-1 |
| Solubility (25°C) | DMSO 80 mg/mL |
| Storage | 4°C, sealed |
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