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M1069

Cat. No. M40651
M1069 Structure
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Biological Activity

M1069 is an orally active, potent, and selective adenosine receptor A2A/A2B antagonist, with more than 100-fold selectivity over A1 and A3 subtypes. In addition, M1069 is able to antagonize adenosine-induced immunosuppression and has antitumor activity, which can be used in solid tumor research.

Chemical Information
Molecular Weight 430.52
Formula C21H26N4O4S
CAS Number 2459881-03-7
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Fatiha Benghanem et al. Acta Crystallogr Sect E Struct Rep Online. Aqua-{4,4'-dimeth-oxy-2,2'-[pyridine-2,3-diylbis(nitrilo-methanylyl-idene)]-diphenolato}copper(II)

[2] Youcef Zidane et al. Acta Crystallogr Sect E Struct Rep Online. Dimeric (2-cyano-phenolato-κO){2,2'-[ethyl-enebis(nitrilo-methyl-idyne)]diphenolato-κO,N,N',O'}manganese(III) monohydrate

[3] Shie Fu Lush et al. Acta Crystallogr Sect E Struct Rep Online. Poly[(μ(3)-5-amino-isophthalato-κO,O':O'':O''')[μ(2)-1,2-bis-(4-pyrid-yl)ethane-κN:N']cobalt(II)]

[4] Xiao-Ping Li et al. Acta Crystallogr Sect E Struct Rep Online. catena-Poly[[[triaqua-(4,5-diaza-fluorene-9-one)cadmium]-μ-benzene-1,3-dicarboxyl-ato] dihydrate]

[5] Feng Wang et al. Acta Crystallogr Sect E Struct Rep Online. Trisodium bis-{1-[iminio-(morpholino)meth-yl]guanidinium} bis-[hexa-hydrogen-hexa-molybdoaluminate(III)] chloride icosa-hydrate

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  Catalog
Abmole Inhibitor Catalog




Keywords: M1069 supplier, Adenosine Receptor, inhibitors, activators


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