LY2452473 is an orally bioavailable, selective androgen receptor modulator (SARM).
| Molecular Weight | 374.44 |
| CAS Number | 1029692-15-6 |
| Solubility (25°C) | DMSO 62.5 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related Androgen Receptor Products |
|---|
| BMS-986365
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| Androstenone
Androstenone is a steroid pheromone and also a metabolite of androgens. |
| (Des-Glu5)-ACTH (1-24) (human, bovine, rat)
(Des-Glu5)-ACTH (1-24) (human, bovine, rat) is an analogue of Adrenocorticotropic hormone (ACTH). |
| Acetyl-ACTH (2-24) (human, bovine, rat)
Acetyl-ACTH (2-24) (human, bovine, rat) is a fragment of proopiomelanocortin (POMC) peptide. |
| Acetyl-ACTH (3-24) (human, bovine, rat)
Acetyl-ACTH (3-24) (human, bovine, rat) is a fragment of proopiomelanocortin (POMC) peptide. |
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