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Lusutrombopag

Cat. No. M9458
Lusutrombopag Structure
Synonym:

S-888711

Size Price Availability
2mg USD 110  USD110 4-7 Days
5mg USD 200  USD200 4-7 Days
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Lusutrombopag is an orally bioavailable thrombopoietin (TPO) receptor agonist. Lusutrombopag acts selectively on the human TPO receptor and activates signal transduction pathways that promote the proliferation and differentiation of bone marrow cells into megakaryocytes.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 591.55
Formula C29H32Cl2N2O5S
CAS Number 1110766-97-6
Purity >99%
Solubility DMSO ≥ 15 mg/mL
Storage at -20°C
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Eltrombopag Olamine

Eltrombopag olamine is a small-molecule, nonpeptide thrombopoietin receptor agonist with megakaryopoiesis-stimulating activity.

Dabigatran Etexilate

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Eltrombopag

Eltrombopag is a member of the biarylhydrazone class, which is a nonpeptide agonist of the thrombopoietin receptor (TpoR).

BIBR 953

BIBR 953 (Dabigatran, Pradaxa) is an oral anticoagulant from the class of the direct thrombin inhibitors.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Lusutrombopag, S-888711 supplier, Thrombopoietin/Thrombin, inhibitors

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