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Lubiprostone

Cat. No. M3459

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Lubiprostone Structure
Synonym:

CAS# 333963-40-9

Size Price Availability Quantity
5mg USD 60  USD60 In stock
10mg USD 95  USD95 In stock
25mg USD 220  USD220 In stock
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Biological Activity

Lubiprostone (Amitiza) is a gastrointestinal agent used for the treatment of idiopathic chronic constipation. It is a bicyclic fatty acid (more precisely, prostaglandin E1) derivative that acts by specifically activating ClC-2 chloride channels on the apical aspect of gastrointestinal epithelial cells, producing a chloride-rich fluid secretion. These secretions soften the stool, increase motility, and promote spontaneous bowel movements (SBM).

Another CAS# 333963-40-9

Chemical Information
Molecular Weight 390.46
Formula C20H32F2O5
CAS Number 136790-76-6
Solubility (25°C) DMSO 70 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Jamal MM, et al. Am J Gastroenterol. A randomized, placebo-controlled trial of lubiprostone for opioid-induced constipation in chronic noncancer pain.

[2] Cryer B, et al. Pain Med. A randomized study of lubiprostone for opioid-induced constipation in patients with chronic noncancer pain.

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Keywords: Lubiprostone, CAS# 333963-40-9 supplier, inhibitors, activators

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