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LSN3318839

Cat. No. M11428
LSN3318839  Structure
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  • MSDS
Biological Activity

LSN3318839 is an orally active allosteric modulator of glucagon-like peptide-1 receptor (GLP-1R).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 480.39
Formula C26H23Cl2N3O2
CAS Number
Purity N/A
Solubility N/A
Storage at -20°C
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