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LSKL, Inhibitor of Thrombospondin (TSP-1) TFA

Cat. No. M14946
LSKL, Inhibitor of Thrombospondin (TSP-1) TFA Structure
Synonym:

TSP-1

Size Price Availability Quantity
5mg USD 100  USD100 In stock
10mg USD 145  USD145 In stock
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Quality Control & Documentation
Biological Activity

LSKL, Inhibitor of Thrombospondin (TSP-1) TFA is a latency-associated protein (LAP)-TGFβ derived tetrapeptide and a competitive TGF-β1 antagonist. LSKL, Inhibitor of Thrombospondin (TSP-1) TFA inhibits the binding of TSP-1 to LAP and alleviates renal interstitial fibrosis and hepatic fibrosis. LSKL, Inhibitor of Thrombospondin (TSP-1) TFA suppresses subarachnoid fibrosis via inhibition of TSP-1-mediated TGF-β1 activity, prevents the development of chronic hydrocephalus and improves long-term neurocognitive defects following subarachnoid hemorrhage (SAH). LSKL, Inhibitor of Thrombospondin (TSP-1) TFA can readily crosse the blood-brain barrier.

Chemical Information
Molecular Weight 572.62
Formula C23H43F3N6O7
CAS Number 283609-79-0 (free base)
Solubility (25°C) DMSO ≥ 150 mg/mL
Water 90 mg/mL
Storage -20°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

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Keywords: LSKL, Inhibitor of Thrombospondin (TSP-1) TFA, TSP-1 supplier, TGF-beta/Smad, inhibitors, activators


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