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Loratadine is a histamine H1 receptor antagonist, used to treat allergies. Also acts as a selective inhibitor of B(0)AT2 with IC50 of 4 μM.
| Molecular Weight | 382.88 |
| Formula | C22H23ClN2O2 |
| CAS Number | 79794-75-5 |
| Solubility (25°C) | 76 mg/mL in Ethanol |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Patel JZ, et al. Bioorg Med Chem Lett. Loratadine analogues as MAGL inhibitors.
| Related Histamine Receptor Products |
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| Dimethindene
Dimethindene is a potent, selective histamine H1 antagonist. |
| ABT-288
ABT-288 is a competitive, potent and selective histamine H3 receptor (H3R) antagonist. |
| A-349821
A-349821 is a histamine H3 receptor antagonist characterized as a radioligand ([3H]-A-349821) for in vivo receptor occupancy assessment. |
| Betazole
Betazole (Ametazole), a pyrazole analogue of histamine, is an orally active histamine H2 receptor agonist. |
| Tiotidine
Tiotidine (ICI 125211) is a potent and selective antagonist of histamine H2-receptor (pA2=7.3-7.8 for guinea-pig right atrium). |
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