Lisinopril dihydrate is an angiotensin converting enzyme inhibitor that has been used to treat hypertension, congestive heart failure, and heart disease.
| Molecular Weight | 441.52 |
| Formula | C21H35N3O7 |
| CAS Number | 83915-83-7 |
| Solubility (25°C) | 4.4 mg/mL in DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related ACE Products |
|---|
| H-Ile-Pro-Pro-OH hydrochloride
H-Ile-Pro-Pro-OH hydrochloride, a milk-derived peptide, inhibits angiotensin-converting enzyme (ACE) with an IC50 of 5 μM. |
| N-Benzoyl-Gly-His-Leu hydrate
N-Benzoyl-Gly-His-Leu hydrate is a leucine derivative, a polypeptide. |
| Bradykinin potentiator B
Bradykinin potentiator B (Bradykinin potentiating peptide B) is venom of Agkistrodon halys blomhoffi. |
| Abz-FR-K(Dnp)-P-OH
Abz-FR-K(Dnp)-P-OH is an angiotensin I-converting enzyme (ACE) substrate and an internally quenched fluorogenic substrate for real time fluorescent assay. |
| Abz-LFK(Dnp)-OH
Abz-LFK(Dnp)-OH is an angiotensin I-converting enzyme (ACE) peptide substrate. |
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