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Lisinopril dihydrate

Cat. No. M9748
Lisinopril dihydrate Structure
Size Price Availability Quantity
100mg USD 80  USD80 In stock
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Biological Activity

Lisinopril dihydrate is an angiotensin converting enzyme inhibitor that has been used to treat hypertension, congestive heart failure, and heart disease.

Chemical Information
Molecular Weight 441.52
Formula C21H35N3O7
CAS Number 83915-83-7
Solubility (25°C) 4.4 mg/mL in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Sorrenti M, et al. J Pharm Sci. Lisinopril dihydrate: single-crystal x-ray structure and physicochemical characterization of derived solid forms.

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