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Lipofermata

Cat. No. M25468

All AbMole products are for research use only, cannot be used for human consumption.

Lipofermata Structure
Synonym:

SIT-4; 5-bromo-5'-phenyl-3'H-spiro[indole-3,2'-[1,3,4]thiadiazol]-2(1H)-one

Size Price Availability Quantity
1mg USD 68  USD68 In stock
2mg USD 100  USD100 In stock
5mg USD 160  USD160 In stock
10mg USD 290  USD290 In stock
25mg USD 430  USD430 In stock
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Quality Control & Documentation
Biological Activity

Lipofermata is a fatty acid transport protein 2 (FATP2) inhibitor. Lipofermata shows fatty acid transport inhibition with an IC50 of 4.84 μM in Caco-2 cells. Lipofermata shows zinc-specific suppression of antibacterial activity. Lipofermata perturbs zinc homeostasis in E. coli K-12 with a MIC of 16 μM. Lipofermata inhibits C1-BODIPY-C12 transport into C2C12, INS-1E, Caco-2 and HepG2 cells at comparable levels yielding sigmoidal dose-response curves with IC50s in the low micromolar range (IC50=2.74-39.34 μM).

Chemical Information
Molecular Weight 360.23
Formula C15H10BrN3OS
CAS Number 297180-15-5
Form Solid
Solubility (25°C) DMSO 90 mg/mL
Storage Powder -20°C
References

[1] Jiyoon L Kim, et al. J Biol Chem. Fatty acid transport protein 2 interacts with ceramide synthase 2 to promote ceramide synthesis

[2] Fernando Santos-Beneit, et al. Sci Rep. A metabolic modeling approach reveals promising therapeutic targets and antiviral drυgs to combat COVID-19

[3] Adeleye Oluwatosin Adeshakin, et al. Data Brief. Lipidomics data showing the effect of lipofermata on myeloid-derived suppressor cells in the spleens of tumor-bearing mice

[4] Maomao Zhang, et al. Cancer Discov. Adipocyte-Derived Lipids Mediate Melanoma Progression via FATP Proteins

[5] Constance Ahowesso, et al. Biochem Pharmacol. Chemical inhibition of fatty acid absorption and cellular uptake limits lipotoxic cell death

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Keywords: Lipofermata, SIT-4; 5-bromo-5'-phenyl-3'H-spiro[indole-3,2'-[1,3,4]thiadiazol]-2(1H)-one supplier, Antibiotic, inhibitors, activators

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