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lipid 10a

Cat. No. M21315
lipid 10a Structure
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Biological Activity

“lipid 10a” (Arcturus tunable lipid for RNA drug delivery).

Chemical Information
Solubility (25°C) N/A
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Shivangi Yadav, et al. NPJ Breast Cancer. Lipid exposure activates gene expression changes associated with estrogen receptor negative breast cancer

[2] Qing Xu, et al. Front Mol Biosci. miR-10a-5p Inhibits the Differentiation of Goat Intramuscular Preadipocytes by Targeting KLF8 in Goats

[3] Wanfu Wu, et al. Proc Natl Acad Sci U S A. Drivers and suppressors of triple-negative breast cancer

[4] Saverio Cinti. Trends Endocrinol Metab. Pink Adipocytes

[5] Yuanyuan Wei, et al. Circulation. Dicer in Macrophages Prevents Atherosclerosis by Promoting Mitochondrial Oxidative Metabolism

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