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Lin28-let-7 antagonist 1 (compound 1632) is a potent antagonist of Lin28/pre-let-7 interaction. Lin28-let-7 antagonist 1 inhibits Lin28A binding to pre-let-7a-2, with an IC50 of 8 μM. Lin28-let-7 antagonist 1 inhibits proliferation in human cancer cells.
| Molecular Weight | 281.31 |
| Formula | C15H15N5O |
| CAS Number | 108825-65-6 |
| Form | Solid |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[4] Martina Roos, et al. ACS Chem Biol. A Small-Molecule Inhibitor of Lin28
[5] Liem H Nguyen, et al. Transl Pediatr. Lin28 and let-7 in cell metabolism and cancer
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