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Lidoflazine is an antianginal calcium channel blocker that carries a significant risk of QT interval prolongation and ventricular arrhythmia. It prolongs QT interval by blocking HERG channel. IC50 < 0.1 μM
| Molecular Weight | 491.62 |
| Formula | C30H35F2N3O |
| CAS Number | 3416-26-0 |
| Solubility (25°C) | DMSO: ≥10 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] M St-Onge, et al. Treatment for calcium channel blocker poisoning: a systematic review
[2] John M Ridley, et al. Lidoflazine is a high affinity blocker of the HERG K(+)channel
[3] F L Gobel, et al. The pathophysiology of angina pectoris and the effect of lidoflazine
[4] R O Cannon 3rd, et al. Beneficial and detrimental effects of lidoflazine in microvascular angina
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