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Levofloxacin

Cat. No. M3298

All AbMole products are for research use only, cannot be used for human consumption.

Levofloxacin Structure
Synonym:

Fluoroquinolone; (-)-Ofloxacin

Size Price Availability Quantity
10mM*1mL in DMSO USD 45  USD45 In stock
100mg USD 40  USD40 In stock
500mg USD 48  USD48 In stock
1g USD 55  USD55 In stock
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Biological Activity

Levofloxacin (Levaquin) is a synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. Levofloxacin inhibits bacterial type II topoisomerases, topoisomerase IV and DNA gyrase. Levofloxacin, like other fluoroquinolones, inhibits the A subunits of DNA gyrase, two subunits encoded by the gyrA gene. This results in strand breakage on a bacterial chromosome, supercoiling, and resealing; DNA replication and transcription is inhibited.

Chemical Information
Molecular Weight 361.37
Formula C18H20FN3O4
CAS Number 100986-85-4
Solubility (25°C) DMSO 10 mg/mL
Water 7 mg/mL
Storage 2-8°C, protect from light, sealed
References

[1] Andrejs Sitovs, et al. Levofloxacin in veterinary medicine: a literature review

[2] Irene Karampela, et al. Could Respiratory Fluoroquinolones, Levofloxacin and Moxifloxacin, Prove to be Beneficial as an Adjunct Treatment in COVID-19?

[3] Andrew C Bennett, et al. An evaluation of reports of ciprofloxacin, levofloxacin, and moxifloxacin-association neuropsychiatric toxicities, long-term disability, and aortic aneurysms/dissections disseminated by the Food and Drug Administration and the European Medicines Agency

[4] Devyani Deshpande, et al. Levofloxacin Pharmacokinetics/Pharmacodynamics, Dosing, Susceptibility Breakpoints, and Artificial Intelligence in the Treatment of Multidrug-resistant Tuberculosis

[5] Mehran Izadi, et al. Levofloxacin Versus Ceftriaxone and Azithromycin Combination in the Treatment of Community Acquired Pneumonia in Hospitalized Patients

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Keywords: Levofloxacin, Fluoroquinolone; (-)-Ofloxacin supplier, Anti-infection, inhibitors, activators

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