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Levalbuterol hydrochloride

Cat. No. M2808
Levalbuterol hydrochloride Structure
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50mg USD 220  USD220 Out of stock
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Quality Control & Documentation
Biological Activity

Levalbuterol HCl is a relatively selective beta2-adrenergic receptor agonist that may be used in asthma-related studies.

Chemical Information
Molecular Weight 275.77
Formula C13H21NO3.HCl
CAS Number 50293-90-8
Solubility (25°C) DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] No authors listed. Levalbuterol

[2] Kana Ram Jat, et al. Levalbuterol versus albuterol for acute asthma: a systematic review and meta-analysis

[3] D A Handley, et al. Levalbuterol hydrochloride

[4] D Slattery, et al. Levalbuterol hydrochloride

[5] H S Nelson. Clinical experience with levalbuterol

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