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Leuprolide acetate is a GnRH analog; leuprolide acetate acts as an agonist at pituitary GnRH receptors.
Prostate. 2021 Sep;81(12):902-912.
Gonadotropin-releasing hormone antagonist associated with lower cardiovascular risk compared with gonadotropin-releasing hormone agonist in prostate cancer: A nationwide cohort and in vitro study
Leuprolide Acetate purchased from AbMole
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Source | Prostate (2021). Figure 5. leuprolide (Abmole Bioscience) |
| Method | Cell invasion assay | |
| Cell Lines | THP 1 cells | |
| Concentrations | 1000 nM | |
| Incubation Time | 72 h | |
| Results | Additional inclusion of leuprolide (1000 nM) during the 72h invasion period more significantly increased the invasive ability of THP 1 cells |
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Source | Prostate (2021). Figure 4. leuprolide (Abmole Bioscience) |
| Method | Cell invasion assay | |
| Cell Lines | THP 1 cells | |
| Concentrations | 1000 nM | |
| Incubation Time | 72 h | |
| Results | Pretreatment of THP1 cells with leuprolide (1000 nM), but not degarelix, significantly increased the MMP9 activity |
| Molecular Weight | 1269.45 |
| Formula | C61H88N16O14 |
| CAS Number | 74381-53-6 |
| Solubility (25°C) | DMSO 10 mg/mL |
| Storage | -20°C, protect from light, dry, sealed |
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