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Leuprolide Acetate

Cat. No. M5735
Leuprolide Acetate Structure
Synonym:

Leuprorelin acetate

Size Price Availability Quantity
5mg USD 80  USD80 In stock
10mg USD 120  USD120 In stock
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Quality Control & Documentation
Biological Activity

Leuprolide acetate is a GnRH analog; leuprolide acetate acts as an agonist at pituitary GnRH receptors.

Product Citations
Customer Product Validations & Biological Datas
Source Prostate (2021). Figure 5. leuprolide (Abmole Bioscience)
Method Cell invasion assay
Cell Lines THP 1 cells
Concentrations 1000 nM
Incubation Time 72 h
Results Additional inclusion of leuprolide (1000 nM) during the 72h invasion period more significantly increased the invasive ability of THP 1 cells
Source Prostate (2021). Figure 4. leuprolide (Abmole Bioscience)
Method Cell invasion assay
Cell Lines THP 1 cells
Concentrations 1000 nM
Incubation Time 72 h
Results Pretreatment of THP1 cells with leuprolide (1000 nM), but not degarelix, significantly increased the MMP9 activity
Chemical Information
Molecular Weight 1269.45
Formula C61H88N16O14
CAS Number 74381-53-6
Solubility (25°C) DMSO 10 mg/mL
Storage -20°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Kiba A, et al. J Obstet Gynaecol Res. Differential mRNA expression profiling in ovarian endometriotic tissue with versus without leuprolide acetate treatment.

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Keywords: Leuprolide Acetate, Leuprorelin acetate supplier, LHRH/GnRH, inhibitors, activators


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