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Leucinostatin A

Cat. No. M30588

All AbMole products are for research use only, cannot be used for human consumption.

Leucinostatin A Structure
Synonym:

Antibiotic P168

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Quality Control & Documentation
Biological Activity

Leucinostatin A (Antibiotic P168) is a nonapeptide exerting a remarkable activity especially against Candida albicans and Cryptococcus neoformans. Leucinostatin A is a hydrophobic nonapeptide antibiotic. Leucinostatin A inhibits prostate cancer growth through reduction of insulin-like growth factor-I expression in prostate stromal cells. Antiprotozoal activies.

Chemical Information
Molecular Weight 1218.61
Formula C62H111N11O13
CAS Number 76600-38-9
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Cedric Kiss, et al. Acta Crystallogr D Struct Biol. Structure of a hydrophobic leucinostatin derivative determined by host lattice display

[2] Takumi Watanabe, et al. Chem Rec. Catalytic Asymmetric Total Synthesis of Leucinostatin A

[3] Qingkang Lyu, et al. Cell Stress Chaperones. Leucinostatin acts as a co-inducer for heat shock protein 70 in cultured canine retinal pigment epithelial cells

[4] Manabu Kawada, et al. Int J Cancer. Leucinostatin A inhibits prostate cancer growth through reduction of insulin-like growth factor-I expression in prostate stromal cells

[5] P Csermely, et al. Biochim Biophys Acta. The nonapeptide leucinostatin A acts as a weak ionophore and as an immunosuppressant on T lymphocytes

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Keywords: Leucinostatin A, Antibiotic P168 supplier, Antifungal, inhibitors, activators

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