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LDN-211904 oxalate is a potent and selective EphB3 inhibitor with an IC50 of 0.079 µM.LDN-211904 oxalate showed good metabolic stability in mouse liver microsomes.LDN-211904 oxalate was shown to be effective in inhibiting STAT3-activated CSC stemness in combination with cetuximab.
| Molecular Weight | 444.87 |
| Formula | C21H21ClN4O5 |
| CAS Number | 1198408-78-4 |
| Form | Solid |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Ephrin Receptor Products |
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| EphA2 agonist 1
EphA2 agonist 1 is a potent EphA2 receptor agonist.EphA2 agonist 1 is highly active and selective for EphA2 overexpressing glioma cells and stimulates EphA2 phosphorylation. |
| KYL peptide
KYL peptide is an antagonistic peptide that selectively targets EphA4, and its binding to the ligand-binding domain of EphA4 effectively alleviates Aβ-induced synaptic dysfunction and synaptic plasticity defects in AD mice. In addition, KYL peptide can promote nerve regeneration after injury and modulate immune response. |
| Ifabotuzumab
Ifabotuzumab is an IgG1κ antibody (KD=610 pM) targeting EphA3. Ifabotuzumab is able to cause apoptosis of tumor cells and activate antibody-dependent cell-mediated cytotoxicity (ADCC), which disrupts the tumor vascular system. In addition, Ifabotuzumab reduces idiopathic pulmonary fibrosis (IPF) CCR10+ cells and ameliorates pulmonary fibrosis. |
| Eph inhibitor 1
Eph inhibitor 1 is a potent Eph inhibitor. |
| Urolithin D
Urolithin D is competitive and reversible antagonist of EphA receptors. |
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