Inhibitor
| Cat.No. | Name | Information |
|---|---|---|
| M8974 | ALW-II-41-27 | ALW-II-41-27 is a Eph receptor tyrosine kinase inhibitor with an IC50 of 11 nM for EPHA2. |
| M49948 | KYL peptide | KYL peptide is an antagonistic peptide that selectively targets EphA4, and its binding to the ligand-binding domain of EphA4 effectively alleviates Aβ-induced synaptic dysfunction and synaptic plasticity defects in AD mice. In addition, KYL peptide can promote nerve regeneration after injury and modulate immune response. |
| M43494 | Eph inhibitor 1 | Eph inhibitor 1 is a potent Eph inhibitor. |
| M43493 | Urolithin D | Urolithin D is competitive and reversible antagonist of EphA receptors. |
| M29119 | 123C4 | 123C4 is a potent, selective and competitive agonist of the receptor tyrosine kinase EPHA4, with a Ki value of 0.65 μM. |
| M27828 | ALW-II-49-7 | ALW-II-49-7 is a selective EphB2 kinase inhibitor with an EC50 value of 40 nM in cell. |
| M14892 | NVP-BHG712 isomer | NVP-BHG712 isomer, a regioisomer of NVP-BHG712, shows conserved non-bonded binding to EPHA2 and EPHB4. |
| M49950 | EphA2 agonist 1 | EphA2 agonist 1 is a potent EphA2 receptor agonist.EphA2 agonist 1 is highly active and selective for EphA2 overexpressing glioma cells and stimulates EphA2 phosphorylation. |
| M49949 | LDN-211904 oxalate | LDN-211904 oxalate is a potent and selective EphB3 inhibitor with an IC50 of 0.079 µM.LDN-211904 oxalate showed good metabolic stability in mouse liver microsomes.LDN-211904 oxalate was shown to be effective in inhibiting STAT3-activated CSC stemness in combination with cetuximab. |
| M49947 | Ifabotuzumab | Ifabotuzumab is an IgG1κ antibody (KD=610 pM) targeting EphA3. Ifabotuzumab is able to cause apoptosis of tumor cells and activate antibody-dependent cell-mediated cytotoxicity (ADCC), which disrupts the tumor vascular system. In addition, Ifabotuzumab reduces idiopathic pulmonary fibrosis (IPF) CCR10+ cells and ameliorates pulmonary fibrosis. |
| M28752 | UniPR129 | UniPR129 is a potent Eph/ephrin antagonist. UniPR129 has the potential for the research of cancer disease. |
| M20738 | Eph-inhibitor-1 | Eph-inhibitor-1 (Eph inhibitor 2) is an Eph family tyrosine kinase inhibitor that targets Eph receptors. |
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