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Lanreotide

Cat. No. M10248
Lanreotide Structure
Synonym:

Somatuline; Lanreotidum; BIM 23014C

Size Price Availability Quantity
5mg USD 70  USD70 In stock
10mg USD 125  USD125 In stock
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Quality Control & Documentation
Biological Activity

Lanreotide is a somatostatin analogue, acts as an inhibitor of growth hormone (GH).

Chemical Information
Molecular Weight 1096.32
Formula C54H69N11O10S2
CAS Number 108736-35-2
Solubility (25°C) DMSO 80 mg/mL
Water 80 mg/mL
Storage -20°C, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Martyn E Caplin, et al. Endocr Relat Cancer. Anti-tumour effects of lanreotide for pancreatic and intestinal neuroendocrine tumours: the CLARINET open-label extension study

[2] Jaume Capdevila, et al. BMC Cancer. Evaluation of the efficacy and safety of lanreotide in combination with targeted therapies in patients with neuroendocrine tumours in clinical practice: a retrospective cross-sectional analysis

[3] Nan Zheng, et al. J Drug Target. Lanreotide-conjugated PEG-DSPE micelles: an efficient nanocarrier targeting to somatostatin receptor positive tumors

[4] Martyn E Caplin, et al. N Engl J Med. Lanreotide in metastatic enteropancreatic neuroendocrine tumors

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Keywords: Lanreotide, Somatuline; Lanreotidum; BIM 23014C supplier, Somatostatin Receptor, inhibitors, activators


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