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L-Sepiapterin (Sepiapterin) is a precursor of the endothelial nitric oxide synthase (eNOS) cofactor tetrahydrobiopterin (BH4). L-Sepiapterin improves endothelial dysfunction in small mesenteric arteries from db/db mice, and induces angiogenesis. L-Sepiapterin (1-50 μM; 20 minutes) significantly inhibits the phosphorylation of VEGF-A-induced (50 ng/ml) p70S6K. L-Sepiapterin inhibits VEGF-A-induced cell proliferation and migration through NO-independent mechanism.
Sepiapterin (10 mg/kg; p.o. (powder chow); daily for 8 weeks) significantly improves the relaxation to Ach in small mesenteric arteries (SMA) from db/db mice.
| Molecular Weight | 237.22 |
| Formula | C9H11N5O3 |
| CAS Number | 17094-01-8 |
| Solubility (25°C) | DMSO 10 mg/mL |
| Storage | -20°C, protect from light |
| Related Metabolite/Endogenous Metabolite Products |
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