L-proline has been used as a component of HG-DMEM for chondrocyte differentiation and for the culture of chondrocyte-like cells. Proline is a cyclic, non-essential, hydrophobic amino acid. It is a proteinogenic amino acid which is crucial for primary metabolism. In peptide chains, proline residues confer structural constraints and enhance the susceptibility of proximal peptide bonds to protease activity.
| Molecular Weight | 115.13 |
| Formula | C5H9NO2 |
| CAS Number | 147-85-3 |
| Solubility (25°C) | Water 50 mg/mL |
| Storage | RT, protect from light, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[2] Nan Li, et al. L-Proline: An Effective Agent for Frozen and Post-thawed Donkey Semen Storage
[3] Xiulai Chen, et al. Enzymatic production of trans-4-hydroxy-l-proline by proline 4-hydroxylase
[4] Xuedong Chen, et al. l-Proline protects mice challenged by Klebsiella pneumoniae bacteremia
[5] Thi Mai Hoa Bach, et al. Properties, metabolisms, and applications of (L)-proline analogues
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