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L-Methionine γ-lyase

Cat. No. M41043
L-Methionine γ-lyase Structure
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Biological Activity

L-Methionine γ-lyase (Methionine lyase) is a multifunctional enzyme, which belongs to the γ-family of pyridoxal-5’-phosphate (PLP) dependent enzyme.

Chemical Information
CAS Number 42616-25-1
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Louay Abo Qoura et al. Int J Mol Sci. Methionine γ-Lyase-Daidzein in Combination with S-Propyl-L-cysteine Sulfoxide as a Targeted Prodrug Enzyme System for Malignant Solid Tumor Xenografts

[2] Atsushi Okawa et al. J Biosci Bioeng. Characterization and application of l-methionine γ-lyase Q349S mutant enzyme with an enhanced activity toward l-homocysteine

[3] Masao Ishikawa et al. FEMS Microbiol Lett. Inhibitory effect of black cumin (Nigella sativa) seed essential oil on Fusobacterium nucleatum L-methionine-γ-lyase (L-methioninase) activity

[4] Atsushi Okawa et al. Biosci Biotechnol Biochem. Novel method for l-methionine determination using l-methionine decarboxylase and application of the enzyme for l-homocysteine determination

[5] Shiro Kato et al. Anal Biochem. Application of l-methionine γ-lyase in chiral amino acid analysis

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