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L-Histidinol dihydrochloride

Cat. No. M20758

All AbMole products are for research use only, cannot be used for human consumption.

L-Histidinol dihydrochloride Structure

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Quality Control & Documentation
Biological Activity

L-Histidinol dihydrochloride, a structural analogue of the essential amino acid L-histidine, is a reversible inhibitor of protein biosynthesis which evokes disparate responses from non-tumorigenic and tumorigenic cells in culture.

Chemical Information
Molecular Weight 214.09
Formula C6H13Cl2N3O
CAS Number 1596-64-1
Solubility (25°C) DMSO 43 mg/mL
Water 43 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Swapnil V Ghodge, et al. Biochemistry. Structural and mechanistic characterization of L-histidinol phosphate phosphatase from the polymerase and histidinol phosphatase family of proteins

[2] Rie Omi, et al. Biochemistry. Crystal structure of monofunctional histidinol phosphate phosphatase from Thermus thermophilus HB8

[3] R C Warrington, et al. J Natl Cancer Inst. Effects of L-histidinol on the susceptibility of P815 mastocytoma cells to selected anticancer drugs in vitro and in DBA/2J mice

[4] R C Warrington, et al. J Natl Cancer Inst. Reversal of the multidrug-resistant phenotype of Chinese hamster ovary cells by L-histidinol

[5] A Nagai, et al. Arch Biochem Biophys. Purification and characterization of histidinol dehydrogenase from cabbage

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Keywords: L-Histidinol dihydrochloride supplier, inhibitors, activators

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