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L-Dopa ethyl ester

Cat. No. M8227

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L-Dopa ethyl ester Structure

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Quality Control & Documentation
Biological Activity

L-Dopa ethyl ester is a precursor compound of levodopa, which has a high gastric solubility. The drug is rapidly hydrolyzed to levodopa in the gastrointestinal tract by nonspecific esterase. Levodopa-carbidopa treatment was well tolerated, but did not show superior efficacy compared to standard levodopa-carbidopa treatment. L-dopa should have significant cerebral penetration after injection.

Chemical Information
Molecular Weight 225.24
Formula C11H15NO4
CAS Number 37178-37-3
Solubility (25°C) Water: ≥12 mg/mL at warmed to 60 °C
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Nunzio Denora, et al. Novel L-Dopa and dopamine prodrugs containing a 2-phenyl-imidazopyridine moiety

[2] K Kawai, et al. Synthesis and evaluation of radioiodinated 6-iodo-L-DOPA as a cerebral L-amino acid transport marker

[3] D R Cooper, et al. L-dopa esters as potential prodrugs: effect on brain concentration of dopamine metabolites in reserpinized mice

[4] D R Cooper, et al. L-dopa esters as potential prodrugs: behavioural activity in experimental models of Parkinson's disease

[5] J A Fix, et al. Short-chain alkyl esters of L-dopa as prodrugs for rectal absorption

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