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KT5823 is a selective the cGMP-dependent protein kinase (PKG) inhibitor with an Ki value of 0.23 μM, it also inhibits PKA and PKC with Ki values of 10 μM and 4 μM, respectively. KT5823 inhibits guanosine monophosphate (GMP)-dependent protein kinase activity (cGK). It is a staurosporine compound, which promotes the thyroid-stimulating hormone and regulates Na+/I− symporter (NIS) expression.
| Molecular Weight | 495.53 |
| Formula | C29H25N3O5 |
| CAS Number | 126643-37-6 |
| Form | Solid |
| Solubility (25°C) | ethyl acetate: 5 mg/mL DMSO 1 mg/mL |
| Storage | -20°C, protect from light |
[3] Jianzhen Li, et al. The role of PKG in oocyte maturation of zebrafish
[5] Diego A Golombek, et al. Signaling in the mammalian circadian clock: the NO/cGMP pathway
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| CW 008
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Products are for research use only. Not for human use. We do not sell to patients.
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