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KS15 is an inhibitor of the interactions between cryptochromes (CRYs: CRY1 and CRY2) and the CLOCK:BMAL1 heterodimer. KS15 impairs the feedback actions of CRYs on E-box-dependent transcription (EC50=4.9 μM) by CLOCK:BMAL1 heterodimer, an indispensable transcriptional regulator of the mammalian circadian clock. Anti-proliferative activity.
| Molecular Weight | 420.3 |
| Formula | C20H22BrNO4 |
| CAS Number | 1033781-20-2 |
| Form | Liquid |
| Solubility (25°C) | DMSO 100 mg/mL (ultrasonic) |
| Storage | -20°C, dry, sealed |
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