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KKL-35

Cat. No. M19923
KKL-35 Structure
Size Price Availability Quantity
5mg USD 220  USD220 In stock
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Quality Control & Documentation
Biological Activity

KKL-35 inhibits the trans-translation tagging reaction with an IC50 of 0.9 µM. It has broad-spectrum antibiotic activity.

Chemical Information
Molecular Weight 317.7
Formula C15H9ClFN3O2
CAS Number 865285-29-6
Solubility (25°C) DMSO 32 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Romain Brunel, et al. Antimicrob Agents Chemother. KKL-35 Exhibits Potent Antibiotic Activity against Legionella Species Independently of trans-Translation Inhibition

[2] Kevin Mac, et al. J Mol Biol. A Genetic Tool to Quantify trans-Translation Activity in Vivo

[3] John N Alumasa, et al. ACS Infect Dis. Ribosome Rescue Inhibitors Kill Actively Growing and Nonreplicating Persister Mycobacterium tuberculosis Cells

[4] Nitya S Ramadoss, et al. Proc Natl Acad Sci U S A. Small molecule inhibitors of trans-translation have broad-spectrum antibiotic activity

[5] George A Naclerio, et al. ACS Infect Dis. Comparative Studies to Uncover Mechanisms of Action of N-(1,3,4-Oxadiazol-2-yl)benzamide Containing Antibacterial Agents

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  Catalog
Abmole Inhibitor Catalog




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