KF 17837

Cat. No. M9671

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Quality Control & Documentation

Purity: >97%
COA
MSDS

Product Information

Biological Activity

KF 17837

Chemical Information

Molecular Weight	386.44
Formula	C20H26N4O4
CAS Number	152881-18-0
Storage	Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month

Conversion of different model animals based on BSA (PMID: 27057123)

Species	Mouse	Rat	Rabbit	Guinea pig	Hamster	Dog
Weight (kg)	0.02	0.15	1.8	0.4	0.08	10
Body Surface Area (m²)	0.007	0.025	0.15	0.05	0.02	0.5
K_m factor	3	6	12	8	5	20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B K_m
	Animal A K_m

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the K_m factor for a mouse and then divide by the K_m factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Trinity J Bivalacqua, et al. Vasodilator responses to adenosine and hyperemia are mediated by A(1) and A(2) receptors in the cat vascular bed

[2] Y Kuwana, et al. Antiparkinsonian activity of adenosine A2A antagonists in experimental models

[3] G De Sarro, et al. Effects of adenosine receptor agonists and antagonists on audiogenic seizure-sensible DBA/2 mice

[4] S Stone-Elander, et al. In vivo biodistribution of [N-11C-methyl]KF 17837 using 3-D-PET: evaluation as a ligand for the study of adenosine A2A receptors

[5] S Dionisotti, et al. Effects of the new A2 adenosine receptor antagonist 8FB-PTP, an 8 substituted pyrazolo-triazolo-pyrimidine, on in vitro functional models

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KF 17837

Quality Control & Documentation

Biological Activity

Chemical Information

Conversion of different model animals based on BSA (PMID: 27057123)

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