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Kasugamycin hydrochloride

Cat. No. M19916
Kasugamycin hydrochloride Structure
Size Price Availability Quantity
1mg USD 155  USD155 In stock
5mg USD 450  USD450 In stock
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Quality Control & Documentation
Biological Activity

Kasugamycin is an aminoglycosidic antibiotic isolated from Streptomyces kasugaensis, showing broad-spectrum anti-fungal activity against yeast and various fungus species.

Chemical Information
Molecular Weight 415.82
Formula C14H26ClN3O9
CAS Number 19408-46-9
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Huitang Qi, et al. Front Mol Biosci. Discovery of Kasugamycin as a Potent Inhibitor of Glycoside Hydrolase Family 18 Chitinases

[2] Suzanne M Slack, et al. Plant Dis. Effect of Kasugamycin, Oxytetracycline, and Streptomycin on In-orchard Population Dynamics of Erwinia amylovora on Apple Flower Stigmas

[3] Guofeng Chen, et al. Environ Sci Pollut Res Int. Dissipation and dietary risk assessment of kasugamycin and saisentong in Chinese cabbage

[4] Christian Lange, et al. PLoS One. Effects of Kasugamycin on the Translatome of Escherichia coli

[5] Lei Lu, et al. Bull Environ Contam Toxicol. Residues and dynamics of kasugamycin in chilli and soil

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