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K6PC-5

Cat. No. M8631

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K6PC-5 Structure

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Quality Control & Documentation
Biological Activity

K6PC-5 is a potent and selective sphingosine kinase 1 (SphK1 or SK1) activator that increases keratin 1 and involucrin expression in normal human epidermal keratinocytes cultured in vitro. K6PC-5 promotes differentiation and proliferation of keratinocytes via intracellular Ca2+ signaling.

Chemical Information
Molecular Weight 343.5
Formula C19H37NO4
CAS Number 756875-51-1
Solubility (25°C) DMSO: 20 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Gergely Imre, et al. The sphingosine kinase 1 activator, K6PC-5, attenuates Ebola virus infection

[2] A Di Pardo, et al. Treatment with K6PC-5, a selective stimulator of SPHK1, ameliorates intestinal homeostasis in an animal model of Huntington's disease

[3] Hua Liu, et al. K6PC-5 Activates SphK1-Nrf2 Signaling to Protect Neuronal Cells from Oxygen Glucose Deprivation/Re-Oxygenation

[4] Feng Ji, et al. K6PC-5, a novel sphingosine kinase 1 (SphK1) activator, alleviates dexamethasone-induced damages to osteoblasts through activating SphK1-Akt signaling

[5] Jong-Kyung Youm, et al. K6PC-5, a sphingosine kinase activator, induces anti-aging effects in intrinsically aged skin through intracellular Ca2+ signaling

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Keywords: K6PC-5 supplier, inhibitors, activators

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