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JZP 361

Cat. No. M6859

All AbMole products are for research use only, cannot be used for human consumption.

JZP 361 Structure
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Biological Activity

JZP 361 is a potent and selective reversible MAGL inhibitor (IC50 = 46 nM). Exhibits 35-fold and 150-fold higher selectivity over human FAAH and ABHD6, respectively (IC50 values are 1.79 and 7.24 μM, respectively). Displays affinity for H1 receptors (pA2 = 6.81). Exhibits no activity at cannabinoid receptors at 10 μM.

Chemical Information
Molecular Weight 405.88
Formula C22H20ClN5O
CAS Number 1680193-80-9
Solubility (25°C) DMSO 40.59 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Taliani, et al. J Med Chem. Identification of anxiolytic/nonsedative agents among indol-3-ylglyoxylamides acting as functionally selective agonists at the γ-aminobutyric acid-A (GABAA) α2 benzodiazepine receptor.

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Keywords: JZP 361 supplier, inhibitors, activators

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