All AbMole products are for research use only, cannot be used for human consumption.
JTE 607 dihydrochloride is a cytokine release inhibitor. JTE 607 dihydrochloride inhibits production of IL-1β, IL-8, IL-6, IL-10 and TNFα from LPS-stimulated PBMCs with IC50 values are 5.9, 7.3, 8.8, 9.1 and 11.0 nM, respectively. JTE 607 dihydrochloride reduces proinflammatory cytokine-release and attenuates lung permeability in a rat lung injury model. JTE-607 induces apoptosis in leukemia cells in vitro and prolongs survival in a mouse leukemia model.
| Molecular Weight | 597.36 |
| Formula | C25H31Cl2N3O5.2HCl |
| CAS Number | 188791-09-5 |
| Solubility (25°C) | DMSO 100 mg/mL Water ≥ 20 mg/mL |
| Storage | -20°C, dry, sealed |
| Related IL Receptor/Related Products |
|---|
| IL-17A modulator-2
IL-17A modulator-2 is a IL-17A modulator. IL-17A modulator-2 inhibits the biological action of IL-17A with a pIC50 of 8.3. IL-17A modulator-2 can be used for the research of diseases associated with modulation of IL-17A activity. |
| IL-15-IN-1
IL-15-IN-1 is a potent and selective Interleukin 15 (IL-15) inhibitor, inhibiting the proliferation of IL-15-dependent cells with an IC50 of 0.8 μM. |
| IL-17 modulator 3
IL-17 modulator 3 is an IL-17 modulator. |
| IL-17 modulator 4
IL-17 modulator 4 is a proagent of IL-17 modulator 1. IL-17 modulator 1 is an orally active, highly efficacious IL-17 modulator. IL-17 modulator 4 is promising for the research of IL-17A mediated diseases, including inflammation, autoimmune diseases, infectious diseases, cancer, and precancerous syndrome. |
| IL-17A modulator-3
IL-17A modulator-3 is a IL-17A modulator. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
