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JP1302 

Cat. No. M30631

All AbMole products are for research use only, cannot be used for human consumption.

JP1302  Structure

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Quality Control & Documentation
Biological Activity

JP1302 is a potent, selective, high affinity antagonist of the α2C-adrenoceptor, with a Kb of 16 nM and a Ki of 28 nM for the human α2C-receptor. JP1302 shows antidepressant and antipsychotic-like effects. JP1302 can be used for neuropsychiatric disorders and renal dysfunction research.

Chemical Information
Molecular Weight 368.47
Formula C24H24N4
CAS Number 80259-18-3
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Dylan C Mitchell, et al. Nat Biotechnol. A proteome-wide atlas of drug mechanism of action

[2] Xiaoyu Chen, et al. Cell Rep. Molecular Mechanism for Ligand Recognition and Subtype Selectivity of α2C Adrenergic Receptor

[3] Hidenobu Tsutsui, et al. Eur J Pharmacol. Inhibition of α2C-adrenoceptors ameliorates cisplatin-induced acute renal failure in rats

[4] Joanna Raczak-Gutknecht, et al. Dose Response. Are Alpha-2D Adrenoceptor Subtypes Involved in Rat Mydriasis Evoked by New Imidazoline Derivatives: Marsanidine and 7-Methylmarsanidine?

[5] Michiko Nakamura, et al. J Neurochem. α(2A) adrenoceptor-mediated presynaptic inhibition of GABAergic transmission in rat tuberomammillary nucleus neurons

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  Catalog
Abmole Inhibitor Catalog




Keywords: JP1302  supplier, Adrenergic Receptor, inhibitors, activators

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