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JNJ-47965567 is a potent and selective P2X7 antagonist (pIC50 values are 8.3, 7.5 and 7.2 for human, mouse and rat receptors respectively). Selective over a panel of 50 other receptors, ion channels and transporters. JNJ-47965567 reduces BzATP-induced IL-1β release from monocytes in vitro and from rat brain in vivo. JNJ-47965567 attenuates amphetamine-induced hyperactivity in rats. Brain penetrant.
| Molecular Weight | 488.64 |
| Formula | C28H32N4O2S |
| CAS Number | 1428327-31-4 |
| Form | Solid |
| Solubility (25°C) | DMSO 80 mg/mL 1eq. HCl 20 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related P2 Receptor Products |
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| NF449
NF449 is a highly potent P2X1 receptor antagonist, with IC50s of 0.28, 0.69, and 120 nM for rP2X1, rP2X1+5, P2X2+3, respectively. |
| NF279
NF279 is a potent selective and reversible P2X1 receptor antagonist, with an IC50 of 19 nM. |
| NF110
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| PSB-12062
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| NF449 octasodium
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Products are for research use only. Not for human use. We do not sell to patients.
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