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JM6

Cat. No. M8381
JM6 Structure
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Biological Activity

JM6 is a prodrug inhibitor of Kynurenine 3-monooxygenase (KMO) that increases kynurenine acid levels and reduces extracellular glutamate in the brain. JM6 prevents spatial memory deficits, anxiety-related behaviors, and synaptic deletions in mouse models of Alzheimer's disease.

Chemical Information
Molecular Weight 518.61
Formula C23H26N4O6S2
CAS Number 1008119-83-2
Solubility (25°C) DMSO: 2 mg/mL (warmed)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Stacy L Sell, et al. MicroRNA profiling identifies a novel compound with antidepressant properties

[2] Valentina Vengeliene, et al. Metabolic shift of the kynurenine pathway impairs alcohol and cocaine seeking and relapse

[3] Yanbing Zhu, et al. Molecular cloning and characterization of a new and highly thermostable esterase from Geobacillus sp. JM6

[4] Maria G Beconi, et al. Metabolism and pharmacokinetics of JM6 in mice: JM6 is not a prodrug for Ro-61-8048

[5] Daniel Zwilling, et al. Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration

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Keywords: JM6 supplier, inhibitors, activators


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