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J 147 is a potent, orally active neuroprotective and neurotrophic compound. Protects against neurotoxicity in cortical neurons in vitro (EC50 = 60 - 115 nM). J-147 reduces soluble Aβ40 and Aβ42 levels and increases BDNF levels in the hippocampus in vivo. J 147 enhances memory in wild type rats. J-147 prevents memory deficits and rescues cognitive deficits in young and aged transgenic Alzheimer's disease mice, respectively.
| Molecular Weight | 350.33 |
| Formula | C18H17F3N2O2 |
| CAS Number | 1146963-51-0 |
| Solubility (25°C) | DMSO 30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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