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Izencitinib

Cat. No. M10837
Izencitinib  Structure
Synonym:

TD-1473

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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Izencitinib (TD-1473) is an orally active, nonselective, gut-defined JAK inhibitor. Izencitinib (TD-1473) can be used in ulcerative colitis studies.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 402.5
Formula C22H26N8
CAS Number 2051918-33-1
Purity >98%
Solubility DMSO ≥ 20 mg/mL
Storage at -20°C
References

[1] Rhiannon N Hardwick, et al. Toxicol Sci. Gut-Selective Design of Orally-Administered Izencitinib (TD-1473) Limits Systemic Exposure and Effects of Janus Kinase Inhibition in Nonclinical Species

[2] Giulia Roda, et al. Expert Rev Gastroenterol Hepatol. JAK selectivity: more precision less troubles

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  Catalog
Abmole Inhibitor Catalog




Keywords: Izencitinib , TD-1473 supplier, JAK, inhibitors

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