Free shipping on all orders over $ 500

Izencitinib

Cat. No. M10837
Izencitinib  Structure
Synonym:

TD-1473

Size Price Availability Quantity
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Izencitinib (TD-1473) is an orally active, nonselective, gut-defined JAK inhibitor. Izencitinib (TD-1473) can be used in ulcerative colitis studies.

Chemical Information
Molecular Weight 402.5
Formula C22H26N8
CAS Number 2051918-33-1
Solubility (25°C) DMSO ≥ 20 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Rhiannon N Hardwick, et al. Toxicol Sci. Gut-Selective Design of Orally-Administered Izencitinib (TD-1473) Limits Systemic Exposure and Effects of Janus Kinase Inhibition in Nonclinical Species

[2] Giulia Roda, et al. Expert Rev Gastroenterol Hepatol. JAK selectivity: more precision less troubles

Related JAK Products
SDC-1802

SDC-1802 is a JAK1/TYK2 inhibitor that can be used in studies related to systemic lupus erythematosus.

OST-246

OST-246 is an inhibitor of JAK3, MAP3K11, and TYK2 for studies related to autoimmune diseases and inflammation.

NDI-031232

NDI-031232 is a TYK2 inhibitor.

NDI-031301

NDI-031301 is a TYK2 inhibitor.

NDI-031407

NDI-031407 is a TYK2 inhibitor for studies related to endocrine metabolic diseases and psoriasis.

  Catalog
Abmole Inhibitor Catalog




Keywords: Izencitinib , TD-1473 supplier, JAK, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.