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Cat. No. M10837
Izencitinib  Structure


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Biological Activity

Izencitinib (TD-1473) is an orally active, nonselective, gut-defined JAK inhibitor. Izencitinib (TD-1473) can be used in ulcerative colitis studies.

Chemical Information
Molecular Weight 402.5
Formula C22H26N8
CAS Number 2051918-33-1
Solubility (25°C) DMSO ≥ 20 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Rhiannon N Hardwick, et al. Toxicol Sci. Gut-Selective Design of Orally-Administered Izencitinib (TD-1473) Limits Systemic Exposure and Effects of Janus Kinase Inhibition in Nonclinical Species

[2] Giulia Roda, et al. Expert Rev Gastroenterol Hepatol. JAK selectivity: more precision less troubles

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Abmole Inhibitor Catalog

Keywords: Izencitinib , TD-1473 supplier, JAK, inhibitors, activators

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