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IWP-3

Cat. No. M8386

All AbMole products are for research use only, cannot be used for human consumption.

IWP-3 Structure

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Quality Control & Documentation
Biological Activity

IWP-3 is a Wnt inhibitor that prevents palmitylation of Wnt proteins by Porcupine (Porcn). IWP-3 is an inactivator of Porcn function that acts as inhibitors of Wnt production. Studies revealed that IWP-3 induces differentiation of human mesoderm cells to form cardiomyocytes.

Chemical Information
Molecular Weight 484.59
Formula C22H17FN4O2S3
CAS Number 687561-60-0
Solubility (25°C) DMSO: 2 mg/mL (warmed)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Karmani Shah, et al. Porcupine inhibitors: Novel and emerging anti-cancer therapeutics targeting the Wnt signaling pathway

[2] Zhoubin Tian, et al. Long non-coding RNA Sox4 promotes proliferation and migration by activating Wnt/β-catenin signaling pathway in osteosarcoma

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Keywords: IWP-3 supplier, inhibitors, activators

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