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Itacitinib adipate

Cat. No. M13853
Itacitinib adipate Structure
Size Price Availability Quantity
5mg USD 140  USD140 In stock
10mg USD 260  USD260 In stock
25mg USD 430  USD430 In stock
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Quality Control & Documentation
Biological Activity

Itacitinib adipate is an orally bioavailable and selective JAK1 inhibitor which has been tested for efficacy and safety in a phase II trial in myelofibrosis.

Chemical Information
Molecular Weight 699.66
CAS Number 1334302-63-4
Solubility (25°C) DMSO ≥ 137.5 mg/mL
Storage 2-8°C, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Tinglei Huang, et al. Cancer Lett. Rab1A promotes IL-4R/JAK1/STAT6-dependent metastasis and determines JAK1 inhibitor sensitivity in non-small cell lung cancer

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Keywords: Itacitinib adipate supplier, JAK, inhibitors, activators

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